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Professor Bi-Fong Lin
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Bi-Fong Lin Professor

Bi-Fong Lin

Title Professor
Education Ph.D., Dept of Nutritional Sciences, University of California at Berkeley
Research Expertise Nutritional chemistry, Nutritional immunology, Cell culture
LAB Nutritional Biochemical Technology Lab.(AC2-409)
TEL +886-2-3366-4451
E-mail bifong@ntu.edu.tw
Personal webpage  

Research


  • Health promoting effects of dietary factors on Immunomodulation: (1) Effects of diets on autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, etc. in murine models; (2) Effects of diets on allergic diseases such as asthma and allergic rhinitis, etc. in murine models; (3) Effects of diets on immunodysregulation-related chronic diseases, such as metabolic syndrome, in murine models.
  • Folate-related studies: (1) Folate status in Taiwan; (2) Folate contents in food; (3) Effects of folate on immune modulations.
  • Screening systems for dietary factors exerting health promoting effects, especially by (1) anti-inflammatory; (2) immunomodulation

Publications


  1. Chan CW, Chan PH, Lin BF*. Folate deficiency increased lipid accumulation and leptin production of adipocytes. Front Nutr 2022, 9:852451. doi:10.3389/fnut.2022.852451. (16/90=17.8%, NUTR & DIET)
  2. Wang LC*, Huang YM, Lu C, Chiang BL, Shen YR, HY Huang, Lee CC, Su NW, Lin BF*. Lower caprylate and acetate levels in the breast milk is associated with atopic dermatitis in infancy. Pediatr Allergy Immunol 2022, 33:e13744. https://doi.org/10.1111/pai.13744. (9/130=6.9% PEDIATR)
  3. Chao WW, Kuo YH, Lin BF*. Isolation and identification of Andrographis paniculata (Chuanxinlian) and its biologically active constituents inhibited enterovirus 71 induced cell apoptosis. Front Pharmacol 2021, doi:10.3389/fphar.2021.762285. (39/279=13.9%, PHARMACOL & PHARMACY)
  4. Wang LC, Chiang BL, Huang YM, Shen PT, Huang HY, Lin BF*. Lower vitamin D levels in the breast milk is associated with atopic dermatitis in early infancy. Pediatr Allergy Immunol, 2020; 31(3): 258-264. (9/130=6.9% PEDIATR)
  5. Huang HY, Hsu T, Lin BF*. Gamma-aminobutyric acid decreases macrophages infiltration and suppresses inflammatory responses in renal injury. J Funct Foods 60, (2019) 103419. doi.org/10.1016/j.jff.2019.103419. (41/144=28.4%, FOOD SCI & TECHNOL)
  6. Hung LH, Wu CH, Lin BF*, Hwang LS*. Hyperimmune colostrum alleviates rheumatoid arthritis in collagen-induced arthritis murine model. J Dairy Sci 2018, 101(5): 3778-3787. https://doi.org/10.3168/jds.2017-13572. (6/63=9%, AGR, Dairy & ANIMAL SCI)
  7. Pan WH, Yeh NH, Lin WH, Yang RY, Lin WH, Wu WC, Yeh WT, Sung MK, Lee HS, Chang SC, Huang CJ, Lin BF, Chiang MT. Vegetable, fruit, and phytonutrient consumption patterns in Taiwan. J Food Drug Analysis 2018, 26(1): 145-153. (5y=6.576, 2021=6.157, 22/144=15%, FOOD SCI & TECHNOL)
  8. Wu CH, Huang TC, Lin BF*. Folate deficiency affects dendritic cell function and subsequent T helper cell differentiation. J Nutr Biochem 2017, 41:65-72.
  9. Lu HY, Lin BF*. Wild bitter melon alleviates dextran sulphate sodium-induced murine colitis by suppressing inflammatory responses and enhancing intestinal regulatory T cells. J Funct Foods 2016, 23:590-600.
  10. Chen ML, Hsieh CC, Chiang BL, Lin BF*. Triterpenoids and polysaccharide fractions of Ganoderma tsugae exert different effects on anti-allergic activities. Evid Based Complement Alternat Med. 2015. 015;2015:754836. doi:10.1155/2015/754836.
  11. Lin BF*, Chiang BL, Ma Y, Lin JY, Chen ML. Traditional herbal medicine and allergic asthma. Evid Based Complement Alternat Med. 2015. 510989. doi: 10.1155/2015/510989.
  12. Chen ML, Wu CH, Hung LS, Lin BF*. Ethanol extract of Perilla frutescens suppresses allergen-specific Th2 responses and alleviates airway inflammation and hyperreactivity in ovalbumin-sensitized murine model of asthma. Evid Based Complement Alternat Med. 2015. 2015:324265. doi: 10.1155/2015/324265.
  13. Wang CH, Hsieh SC, Wang HJ, Chen ML, Lin BF, Chiang BH, Lu TJ*. Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium. J Agric Food Chem. 2014, 62:634-641.
  14. Pan WH*, Chang YP, Yeh WT, Guei YS, Lin BF, Wei IL, Yang FL, Liaw YP, Chen KJ, Chen WJ. Co-occurrence of anemia, marginal vitamin B6, and folate status and depressive symptoms in older adults. J Geriatr Psychiatry Neurol 2012, 25:170-8.
  15. Chao WW, Lin BF*. Hepatoprotective diterpenoids isolated from Andrographis paniculata. Chin Med 2012, 3:136-43.
  16. Hsieh CC, Lin BF*. Dietary factors regulate cytokines in murine models of systemic lupus erythematosus. Autoimmun Rev. 2011,11(1): 22-27.
  17. Chao WW, Lin BF*. Bioactivities of major constituents isolated from Angelica sinensis (Dang gui). Chin Med 2011; 6(1): 29.
  18. Chen KJ*, Pan WH, Lin YC, Lin BF*. Trends of folate status in Taiwanese population aged ³19 yrs from the Nutrition and Health Survey in Taiwan 1993~1996 to 2005~2008. Asia Pac J Clin Nutr 2011; 20 (2): 275-282.
  19. Chao WW, Kuo YH, Hsieh SL, Lin BF*. Inhibitory effects of ethyl acetate extract of Andrographis paniculata on NF-kB trans-activation activity and LPS-induced acute inflammation in mice. Evid Based Complement Alternat Med. 2011, Article ID 254531, doi:10.1093/ecam/nep120
  20. Hong YH, Wang SC, Hsu C, Lin BF, Kuo YH*, Huang CJ*. Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol. J Agric Food Chem. 2011; 59(1): 131-137.
  21. Chen KJ*, Pan WH, Huang CJ, Lin BF*. Association between folate status, diabetes, antihypertensive medication and age-related cataracts in elderly Taiwanese. J Nutr Health Aging, 2011; 15 (4): 304-310.
  22. Chao WW, Lin BF*. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med 2010; 5:17.
  23. Chao WW, Hong YH, Chen ML, Lin BF*. Inhibitory effect of Angelica sinensis ethyl acetate extract and major compounds on NF-kB trans-activation activity and LPS-induced inflammation. J Ethnopharmacol. 2010; 129(2): 244-249.
  24. Chao WW, Kuo YH*, Lin BF*. Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kB trans-activation inhibition. J Agric Food Chem. 2010; 58: 2505-12.
  25. Hong YH, Chao WW, Chen ML and Lin BF*. Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo. J Biomed Sci. 2009;16(1):64.
  26. 呂學耘、洪永瀚、林璧鳳*。攝食水果以提高葉酸攝取量的可行性探討。台灣營養學會雜誌 2009; 34 (2): 58-67.
  27. Chao WW, Kuo YH, Li WC, Lin BF*. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. J Ethnopharmacol 2009; 122:68-75.
  28. Hong YH, Huang CJ, Wang SC and Lin BF*. The ethyl acetate extract of Alfalfa sprouts ameliorates autoimmune-prone disease of MRL-lpr/lpr mice. Lupus 2009; 18(3): 206-15.
  29. Hong YH, Wang TC, Huang CJ, Cheng WY and Lin BF*. Soy isoflavones supplementation alleviates disease severity in autoimmune-prone MRL-lpr/lpr mice. Lupus 2008; 17: 814-21.
  30. Weng LC, Yeh WT, Bai CH, Chen HJ, Chuang SY, Chang HY, Lin BF, Chen KJ, Pan WH*. Is ischemic stroke risk related to folate status or other nutrients correlated with folate intake? Stroke 2008; 39(12): 3152-3158.
  31. Chien SC, Chen ML, Kuo HT, Tsai YC, Lin BF* and Kuo YH*. Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata. J Agric Food Chem. 2008; 56(16): 7017-22.
  32. Lin JY*, Li CY and Lin BF*. Amaranthus spinosus inhibits spontaneous and dexamethason-induced apoptosis in murine primary splenocytes. J Food Drug Analysis 2008; 16 (4): 52-61.
  33. 陳妙齡、林璧鳳*。篩選調節過敏反應食材之細胞培養及小鼠評估方法。臺灣農業化學與食品科學 2007; 45 (6): 316-326.
  34. 吳繼恆、林進忠、林金源、林璧鳳*。膳食油脂的種類與量對卵蛋白致敏BALB/c小鼠過敏免疫反應的影響。台灣營養學會雜誌 2007; 32 (3): 83-93.
  35. 趙文婉、郭悅雄、林璧鳳*。以啟動子轉殖細胞株篩檢調節免疫力之中藥的模式建立。臺灣農業化學與食品科學 2007; 45 (4-5): 193-205.
  36. Chen KJ*, Shaw NS, Pan WH and Lin BF*. Evaluation of folate status by serum and erythrocyte folate levels and dietary folate intake in Taiwanese schoolchildren. Asia Pac J Clin Nutr 2007; 16 (S2): 572-578.
  37. Chen ML and Lin BF*. Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo. Int Arch Allergy and Immunol 2007; 143: 21-30.
  38. 陳冠如*、蕭寧馨、潘文涵、駱菲莉、林璧鳳*。素食飲食型態對台灣老人維生素B營養狀況與血漿同半胱胺酸濃度的影響。台灣營養學會雜誌 2006; 31(4): 117-126.
  39. Lin JY*, Chen ML, Lin BF*. Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model. Food Chem Toxicol 2006; 44: 2025-32.
  40. Hsieh CC, Huang CJ and Lin BF*. Low and high levels of a-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPARg, IkBa and apoptotic pathway in activated splenocytes. Nutrition 2006; 22 (4): 433-440.
  41. 陳妙齡、林金源、林璧鳳*。餵食松杉靈芝對BALB/c小鼠免疫調節的影響。臺灣農業化學與食品科學 2006; 44 (4): 243-249.
  42. 陳冠如、蕭寧馨、林璧鳳*。台北地區醫院產檢孕婦的葉酸營養狀況。中華民國營養學會雜誌 2006; 31 (1): 8-16.
  43. Lin JY*, Chen ML, Chiang BL, Lin BF*. Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. Int Immunopharmacol 2006; 6(1): 241-251.
  44. Hsieh CC and Lin BF*. The effects of vitamin E supplementation on autoimmune-prone NZB/W F1 mice fed an oxidized oil diet. Br J Nutr 2005; 93 (5): 655-662.
  45. Chen KJ, Pan WH, Shaw NS, Huang RF S and Lin BF*. Association between dietary folate-rich food intake and folate status of elderly Taiwanese. Asia Pac J Clin Nutr 2005; 14(3): 244-249.
  46. Chen KJ, Pan WH, Yang FL, Wei IL, Shaw NS and Lin BF*. Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia Pac J Clin Nutr 2005; 14(3): 250-255.
  47. Hsieh CC and Lin BF*. Opposite effects of low- and high-dose supplementation of vitamin E on survival of MRL/lpr mice. Nutrition 2005; 21 (9): 940-948.
  48. Lin BF, Chiang BL and Lin JY*. Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro. Int Immunopharmacol 2005; 5(4): 711-722.
  49. 陳妙齡、謝佳倩、陳冠如、林璧鳳*。年輕人腹部皮脂厚與水分攝取量之相關性探討。中華民國營養學會雜誌 2004; 29(4): 237-243.
  50. 洪永瀚、林璧鳳*。以巨噬細胞株分泌發炎介質篩選抗發炎作用的模式評估。中華民國營養學會雜誌 2004; 29(3): 159-167.
  51. Hsu HY, Lin BF, Lin JY, Kuo CC and Chiang W*. Suppression of allergic reactions by dehulled adlay in association with the balance of Th1/Th2 cell responses. J Agr Food Chem 2003; 51:3763-3769.
  52. 陳怡靜、林璧鳳*。榨汁處理對蔬果膳食纖維可獲率的影響。中華民國營養學會雜誌2003; 28: 18-25.
  53. 林金源、劉怡伶、林璧鳳、蕭正忠、蔡順仁。紅鳳菜及紅莧菜之抗氧化、抗突變及調節小鼠脾臟細胞分泌性能研究。臺灣農業化學與食品科學 2004; 42(4): 231-241.
  54. 洪永瀚、林璧鳳*。稻苗草榨汁對抑制發炎反應的功能研究。臺灣農業化學與食品科學 2004; 42(6): 456-465.
  55. 陳紀樺、林金源、劉蓓璇、楊媛絢、丁懷謙、廖啟成、林璧鳳*。雙叉桿菌餵食對BALB/c鼠之腸道菌叢與免疫調節的影響。臺灣農業化學與食品科學 2003; 41: 336-342.
  56. Ghandour H, Lin BF, Choi SW, Mason JB, Selhub J*. Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. J Nutr 2002; 132:1357-60.
  57. Hung CJ, Huang PC, Lu SC, Li YH, Huang HB, Lin BF, Chang SJ, Chou HF*. Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores. J Nutr 2002; 132:152-158.
  58. Wu WM, Chiang BL, Chang SC and Lin BF*. Dietary fish oil increases CD8+ T cells and decreases autoreactive T cells in autoimmune NZBxNZW F1 mice. J Microbiol, Immunol and Infect 2001; 34(1): 41-49.
  59. Wu WM, Lin BF, Su YC, Suen JL and Chiang BL*. Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand J Immunol 2000; 52: 393-400.
  60. Lin JY and Lin BF*. Effects of the sensitization protocols on the animal model of allergic disease. Food Sci Agr Chem 2000. 2: 165-171.
  61. Wu WM, Chiang BL, Chang SC and Lin BF*. Late feeding of dietary fish oil alleviates disease severity and affects macrophage function in autoimmune NZB/W F1 mice. J Microbiol, Immunol and Infect 2000; 33(2): 79-86.
  62. Wu WM, Suen JL, Lin BF and Chiang BL*. Tamoxifen alleviates disease severity and decreases double negative T cells in autoimmune MRL.lpr/lpr mice. Immunol 2000, 100: 110-8.
  63. Lin BF*, Lai CC, Lin KW and Chiang BL. Dietary oxidized frying oil influence the levels of type 2 T helper cell-related antibody and inflammatory mediators in mice. Brit J Nutr 2000, 84:911-7.
  64. 呂麗琴、林璧鳳*。台灣地區蔬菜之葉酸含量測定。中華民國營養學會雜誌 2000; 25: 29-37.
  65. Lin BF*, Lin RF, Yeh WT and Pan WH. The Folate Status in Taiwanese Population from the NAHSIT 1993-1996. Nutrl Sci J 1999; 24: 99-117.
  66. Chang SC, Chiang BL, Wu WM and Lin BF*. Different dietary fats influence serum and tissue lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/W F1 mice. Brit J Nutr 1999; 81(4): 331-340.
  67. Lin JY and Lin BF*. Effects of the sensitization protocols on the animal model of allergic disease. Food Sci Agr Chem 2000. 2: 165-171.
  68. 林璧鳳*、林榮富。中式油炒烹調對蔬菜中葉酸含量之影響。中國農業化學會誌1999; 37: 443-454.
  69. Lin BF*, Cheng CH, Chiang BL. Effect of dietary soybean oil and fish oil on the immunoglobulin E and pro-inflammatory mediator productions of allergic immunized mice. FASEB Journal 1998; 12(5).
  70. 徐明麗、林璧鳳、江文章*。糙薏芢對致敏鼠過敏反應之影響。中華民國營養學會雜誌1998; 23: 161-170.
  71. Lin BF* and Jeng SJ. Effects of dietary frying oil on lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/W F1 mice. Nutr Res. 1997, 17: 1047-1052.
  72. Lin BF*, Wu IR, Chiang BL, Liu JF and Huang CJ. Effects of dietary oxidized frying oil on immune responses of spleen cells in rats. Nutr Res 1997; 17(4): 729-740.
  73. Lin BF*, Jeng SJ, Chiang BL and Huang CC. Dietary fat affects lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/W F1 mice. Brit J Nutr 1997; 77(4): 657-669.
  74. 賴佳君、林璧鳳*。炸油攝食對 BALB/c 鼠脂質代謝的影響。中華民國營養學會雜誌 1997; 22: 33-46.
  75. 林璧鳳*、張世震、吳文勉。高量之不同膳食油脂對 NZB/W F1 自體免疫傾向鼠肝微粒體cytochrome P450含量與肝維生素E含量及脂質過氧化物的影響。中華民國營養學會雜誌1997; 22:15-31.
  76. 賴佳君、林璧鳳*、林凱瑋。高油與炸油攝食對BALB/c鼠前列腺素E2生成之影響探討。中國農業化學會誌1997; 35: 401-412.
  77. Lin BF*, Huang CC and Chiang BL. Dietary frying oil influences immune regulation in autoimmune-prone NZBxNZW F1 mice. J Microbiol, Immunol and Infect 1996; 29: 123-133.
  78. Lin BF*, Huang CC, Chiang BL and Jeng SJ. Dietary fat influences Ia antigen expression, cytokines and prostaglandin E2 production in autoimmune-prone NZBxNZW F1 mice. Brit J Nutr 1996; 75: 711-722.

  • 上版日期：2023-03-12

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2025-04-23