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Professor Chia-Chien Hsieh
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Chia-Chien Hsieh

Title Professor 
Education Ph.D., Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University
Research Expertise Nutritional biochemistry, Nutrition and cancer, Nutritional immunology
LAB Nutrition and Health lab. (AC2-412)
TEL +886-2-3366-9660
E-mail cchhsieh@ntu.edu.tw
Personal webpage  

Research


  • To set up in vitro and in vivo models for obesity research.
  • Dietary components regulate obesity-related metabolic disorders, immune responses and cancer development.
  • To explore the mechanisms of bioactive function of seed peptide lunasin.

 

  1. The effects of dietary components on obesity-related immune and metabolic disorders
  • Obese population is globally increasing nowadays, who are easily suffering chronic diseases development. During adiposity, adipocytes play an endocrine organ and release mediators such as adipokines, cytokines, and chemokines to recruit multiple immune cells. Immune cells such as macrophages, B cells, and T cells highly infiltrate into the adipose tissues and promote the development of several diseases such as T2DM, metabolic dysfunction, and cancers. We focus on the effects of dietary compounds on immunomodulation, glucose utilization, and metabolites production in obese cellular and mice models.
  1. Dietary components execute chemoprevention of obesity-related cancers
  • In adiposity, adipocytes and surrounding cells cross-talk and secret multiple mediators, facilitated a tumor-favorable microenvironment. We explore that dietary factors intervene in neoplastic cells and animals, and investigate the possible mechanisms of chemoprevention.
  1. To explore the mechanisms of action of seed peptide lunasin
  • Lunasin is a natural peptide that exists in seeds with multiple bioactivities, and has been demonstrated its bio-activities such as anti-tumor, anti-oxidation, anti-inflammation, and anti-cholesterol properties. We focus on the effects of lunasin on obesity-related metabolic and immune disorders, and cancer chemoprevention. The study might contribute to prevent and auxiliary therapy obesity related diseases, and guide the industry to develop effective and convenient supplements.

Publications


  1. Huang PY, Chiang CC, Huang CY, Lin PY, Kuo HC, Kuo CH, Hsieh CC*. (2023). Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders. Life Sciences, 333, 122180. (SCI)
  2. Huang PY, Hsieh CC* (2023). Immunomodulatory effects of seed peptide lunasin in RAW264.7 macrophages in obese microenvironments. Journal of Functional Foods, 108, 105719. (SCI)
  3. Hsieh CC*, Wu CH, Peng SH, Chang CH (2023) Seed-derived peptide lunasin suppressed breast cancer cell growth by regulating inflammatory mediators, aromatase, and estrogen receptors. Food & Nutrition Research. 2023, 67. (SCI)
  4. Hsieh CC*, Wang YF, Lin PY, Peng SH, Chou MJ (2021) Seed peptide lunasin ameliorates obesity-induced inflammation and regulates immune responses in C57BL/6J mice fed high-fat diet. Food and Chemical Toxicology, 147, 111908. (SCI)
  5. Hsieh CC* (2020). Seed peptide lunasin abates obesity-related inflammation and breast cancer progression. Nutrition Sciences Journal, 44(3):62-69.
  6. Hsieh CC*, Chiu HH, Wang CH, Kuo CH (2020) Aspirin modifies inflammatory mediators and metabolomic profiles and contributes to the suppression of obesity-associated breast cancer cell growth. International Journal of Molecular Sciences, 21(13), 4652. (SCI)
  7. Chen SI, Tseng HT, Hsieh CC* (2020) Evaluating the impact of soy compounds on breast cancer using data mining approach. Food & Function, 2020, 11(5):4561-4570. (SCI)
  8. Chen SI, Hsieh CC* (2019) Chemoprevention by means of soy proteins and peptides: current status and future approaches: A Review. International Journal of Food Science & Technology, 2019, 54:1460-1466. Article ID: IJFS14053. (SCI)
  9. Hsieh CC*, Wang CH (2018) Aspirin disrupts the crosstalk of angiogenic and inflammatory cytokines between 4T1 breast cancer cells and macrophages. Mediators of Inflammation, 2018, 6380643. eCollection 2018. (SCI)
  10. Chen SI, Hsieh CC* (2018) Why are women with obesity more likely to develop breast cancer. Future Oncology, 14(16):1523-1526. (SCI)
  11. Hsieh CC, Martínez-Villaluenga C, de Lumen BO, Hernández-Ledesma B (2018) Updating the research on the chemopreventive and therapeutic role of the peptide lunasin. Journal of the Science of Food and Agriculture, 98(6):2070-2079. (SCI)
  12. Hsieh CC*, Peng SH, Chou MJ (2017) Obesity enhances carcinogen 7, 12-Dimethylbenz [a] anthracene -induced tumorigenesis in vitro and in vivo. Food and Chemical Toxicology, 110:156-164. (SCI)
  13. Hernández-Ledesma B, Hsieh CC* (2017) Chemopreventive role of food-derived proteins and peptides: a review. Critical Reviews in Food Science and Nutrition, 57(11):2358-2376. (SCI)
  14. Hsieh CC*, Chou MJ, Wang CH (2017) Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production. PLoS ONE, 12(2): e0171969. (SCI)
  15. Hsieh CC*, Wang CH, Huang YS (2016) Lunasin attenuates obesity-associated metastasis of 4T1 breast cancer cell through anti-inflammatory property. International Journal of Molecular Sciences, 2016, 17(12), pii: E2109. (SCI)
  16. Hsieh CC*, (2016) The interaction of obesity and inflammation in breast cancer. Journal of Medical Oncology and Therapeutics, 1(1):15-18.
  17. Hsieh CC*, Huang YS (2016) Aspirin breaks the cross-talk between 3T3-L1 adipocytes and 4T1 breast cancer cells by regulating cytokines production. PLoS ONE, 11(1):e0147161. (SCI)
  18. Hsieh CC, Hernández-Ledesma B, Fernández-Tomé S, Weinborn V, Barile D, Leite Nobrega de Moura JM (2015) Milk protein, peptides, and oligosaccharides: effects against the 21st century disorders. BioMed Research International, Article ID 146840. (SCI)
  19. Chen ML, Hsieh CC, Chiang BL, Lin BF (2015) Triterpenoids and polysaccharide fractions of Ganoderma tsugae exert different effects on anti-allergic activities, Evidence-Based Complementary and Alternative Medicine, Article ID 754836. (SCI)
  20. Hernández-Ledesma B, Hsieh CC, de Lumen BO (2013) Chemopreventive properties of peptide lunasin: a review. Protein and Peptide Letters, 20(4):424-432. (SCI)
  21. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Chemopreventive role of aspirin and its combinations against cancer. International Journal of Cancer Research and Prevention, 4(4):339-368.
  22. Hernández-Ledesma B, Espartosa DM, Hsieh CC, de Lumen BO, Recio I (2011) Role of peptide lunasin’s antioxidant activity on its chemopreventive properties. Annals of Nutrition and Metabolism, 58 (suppl.3):354. (SCI)
  23. Hsieh CC, Lin BF (2011) Dietary factors regulate cytokines in murine models of systemic lupus erythematosus. Autoimmunity Reviews, 11(1):22-27. (SCI)
  24. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Lunasin-aspirin combination against NIH/3T3 cells transformation induced by chemical carcinogens. Plant Foods for Human Nutrition, 66(2):107-113. (SCI)
  25. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Cell proliferation inhibitory and apoptosis inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells. Food Chemistry, 125(2):630-636. (SCI)
  26. Hernández-Ledesma B, Hsieh CC, de Lumen BO (2011) Relationship between lunasin’s sequence and its inhibitory activity of histones H3 and H4 acetylation. Molecular Nutrition & Food Research, 55(7):989-998. (SCI)
  27. Leite Nobrega de Moura JM, Hernández-Ledesma B, de Almeida NM, Hsieh CC, de Lumen BO, Johnson LA (2011) Lunasin and Bowman-Birk protease inhibitor concentrations of protein extracts from enzyme-assisted aqueous extraction of soybeans. Journal of Agricultural and Food Chemistry, 59(13):6940-6946. (SCI)
  28. Jeong HJ, Jeong JB, Hsieh CC, Hernández-Ledesma B, de Lumen BO (2010) Lunasin is prevalent in barley and is bioavailable and bioactive in in vivo and in vitro studies. Nutrition and Cancer - An International Journal, 62(8):1113-1119.
  29. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2010) Soybean peptide lunasin suppresses in vitro and in vivo 7,12-dimethylbenz[a]anthracene-induced tumorigenesis. Journal of Food Science, 75(9):H311-H316. (SCI)
  30. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2010) Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced-apoptosis. Chemico-Biological Interactions, 186(2):127-134. (SCI)
  31. Hsieh CC, Hernández-Ledesma B, Jeong HJ, Park JH, de Lumen BO (2010) Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable. PLoS ONE, 5(1):e8890. (SCI)
  32. Hernández-Ledesma B, Hsieh CC# (equal contribution), de Lumen BO (2009) Anti-inflammatory and antioxidant properties of peptide lunasin in RAW 264.7 macrophages. Biochemical and Biophysical Research Communications, 390(3):803-808. (SCI)
  33. Hernández-Ledesma B, Hsieh CC, de Lumen BO (2009) Lunasin and Bowman-Birk protease inhibitor (BBI) in US commercial soy foods. Food Chemistry, 115 (2):574-580. (SCI)
  34. Hernández-Ledesma B, Hsieh CC# (equal contribution), de Lumen BO (2009) Lunasin, a novel peptide for cancer prevention. Peptides, 30(2):426-430. (SCI)
  35. Tai CL, Hung MS, Pawar VD, Tseng SL, Song JS, Hsieh WP, Chiu HH, Wu HC, Hsieh MT, Kuo CW, Hsieh CC, Tsao JP, Chao YS, Shia KS (2008) Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists. Organic & Biomolecular Chemistry, 6(3):447-450. (SCI)
  36. Hsieh CC, Huang CJ, Lin BF (2006) Low and high levels of a-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPARg, IkBa and apoptotic pathway in activated splenocytes. Nutrition, 22(4):433-440. (SCI)
  37. Hsieh CC, Lin BF (2005) Opposite effects of low- and high-dose supplementation of vitamin E on survival of MRL/lpr mice. Nutrition, 21(9):940-948. (SCI)
  38. Hsieh CC, Lin BF (2005) The effects of vitamin E supplementation on autoimmune-prone New Zealand black ´ New Zealand white F1 mice fed an oxidised oil diet. British Journal of Nutrition, 93(5):655-662. (SCI)
  39. Chen ML, Hsieh CC, Chen KJ, Lin BF (2004) Association between abdominal skin fold and daily fluid intake in young adults. Nutrition Sciences Journal, 29(4): 237-243.

  • 上版日期：2023-03-12

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2024-11-22