NTUBST2023EN

Our research interest is to understand the mechanistic basis by which epigenetic modifications regulate gene expression during environmental exposure. In particular, we focus on the impacts of nutrients intake on human health and its epigenetic basis. Given that most of the epigenetic alterations can be reversible, dietary intervention with select nutrients may ameliorate disease phenotype. A better understanding the role of nutrients or bioactive food compounds in altering epigenetic patterns is crucial to design effective therapeutic strategies for preventing and treating abnormalities in offspring born to mothers with a previous experience of malnutrition. In our laboratory, we use mouse models combined with in vitro cell culture system to address the biological questions.

1. Li, C.J., Jiang, C.L., Chao, T.L., Lin, S.Y., Tsai, Y.M., Chao, C.S., Su, Y.T., Chen, C.J., Chang, S.Y.*, Lin, F.J.* and Chang, S.C*. Elicitation of potent neutralizing antibodies in obese mice by ISA 51-adjuvanted SARS-CoV-2 spike RBD-Fc vaccine. Applied Microbiology and Biotechnology, May;107(9):2983-2995, 2023 (SCI, IF 5.56, 31/159, Biotechnology & Applied Microbiology, *corresponding author)
2. Lin, F.J.* Programming of Cardiovascular Disease and Nonalcoholic Fatty Liver Disease: The Role of Maternal Nutrition. Nutritional Sciences Journal, 46 (4): 126-137, 2022 (*first & corresponding author)
3. Wei, Y.S., Lin, W.Z., Wang, T.E., Lee, W.Y., Li, S.H., Lin, F.J., Nixon B., Sipila P., and Tsai P.S. Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1. Journal of Reproduction and Development, Jun 1;68(3):198-208, 2022 (SCI, IF 2.22, 23/62, Agriculture, Dairy & Animal Science)
4. Lin, F.J.* Epigenetics: A New Link Between Nutrition and Health. Nutritional Sciences Journal, 45 (4): 122-140, 2021 (*first & corresponding author)
5. Chen, W.T., Tseng, H.Y., Jiang, C.L., Lee, C.Y., Chi, P., Chen, L.Y., Lo, K.Y., Wang, I.C. and Lin, F.J.* Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation. Journal of Biomedical Science Nov 24;28(1):81, 2021 (SCI, IF 12.77, 11/139, Medicine, Research, Experimental, *corresponding author)
6. Jiang, C.L., Chen, Y.F. and Lin, F.J.* Apolipoprotein E deficiency activates thermogenesis of white adipose tissues in mice through enhancing β-hydroxybutyrate production from precursor cells. FASEB Journal Aug;35(8): e21760, 2021 (SCI, IF 5.83, 16/94, Biology, *corresponding author) Research Highlights in Media: https://medicineinnovates.com/burn-calories-fighting-against-obesity-activating-beige-fat-development/
7. Chen, S.Y., Chen, Y.Z., Lee, Y.J., Jiang, C.L., Lu, S.C. and Lin, F.J.* Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype. Journal of Nutritional Biochemistry Apr; 90:108575, 2021 (SCI, IF 6.12, 18/90, Nutrition & Dietetics, *corresponding author)
8. Chen, H.C., Chen, Y. Z., Wang, C.H. and Lin, F.J.* The nonalcoholic fatty liver disease-like phenotype and lowered serum VLDL are associated with decreased expression and DNA hypermethylation of hepatic ApoB in male offspring of ApoE deficient mothers fed a with Western diet. Journal of Nutritional Biochemistry Mar; 77:108319, 2020 (SCI, IF 6.12, 18/90, Nutrition & Dietetics, *corresponding author)
9. Yang, K.T., Inoue, A., Lee, Y.J., Jiang, C.L. and Lin, F.J.* Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorganization, developmental defects in preimplantation embryos and impaired female fertility. Scientific Reports 9, 18875, 2019 (SCI, IF 5.00, 19/74, Multidisciplinary Sciences, *corresponding author)
10. Wang, Y.J., Lee, S.C., Hsu, C.H., Kuo, Y.H., Yang, C.C., and Lin, F.J.* Antcins, Triterpenoids from Antrodia cinnamomea, as New Agonists for Peroxisome Proliferator-Activated Receptor α. Journal of Food and Drug Analysis Jan; 27(1):295-304, 2019 (SCI, IF 6.16, 27/144, Food Science & Technology, *corresponding author)
11. Lin, F.J., Shen, L., Jang, C.W., Falnes,P.Ø. and Zhang, Y. Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression. PLoS Genetics 9(5): e1003516, 2013 (SCI, IF 6.02, 27/175, Genetics & Heredity)
12. Lin, F. J.^#, You, L. R.^#, Yu, C.T., Hsu, W. H., Tsai, M.J., and Tsai, S.Y. Endocardial Cushion Morphogenesis and Coronary Vessel Development Require COUP-TFII. Arteriosclerosis Thrombosis and Vascular Biology 32(11): e135-46, 2012 (^#equal contribution) (SCI, IF 10.51, 5/67, Peripheral Vascular Disease)
13. Lin, F. J., Qin, J., Tang, K., Tsai, S.Y., and Tsai, M.J. COUP D’ETAT: An Orphan Takes Control. Endocrine Reviews. 32(3):404-21, 2011(SCI, IF 25.26, 4/146, Endocrinology & Metabolism)
14. Lin, F. J., Chen, X., Qin, J., Hong, Y. K., Tsai, M.J., and Tsai, S.Y. Direct transcriptional regulation of Nrp2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. Journal of Clinical Investigation 120(5):1694-707, 2010 (SCI, IF 19.48, 2/139, Medicine, Research, Experimental)
15. Li, Y.J., Luo, S.C., Lee, Y.J., Lin, F.J., Cheng, C.C., Wein, Y.S., Kuo, Y.H., and Huang, C.J. Isolation and identification of alpha-CEHC sulfate in rat urine and an improved method for the determination of conjugated alpha-CEHC. Journal of Agricultural and Food Chemistry 56 (23):11105-13, 2008 (SCI, IF 5.90, 6/59, Agriculture, Multidisciplinary)
16. Srinivasan, R.S., Dillard, M.E., Lagutin, O.V., Lin, F.J., Tsai, S.Y., Tsai, M.J., Samokhvalov I.M., and Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes and Development 21(19):2422-32, 2007 (SCI, IF 12.89, 2/39, Developmental Biology)
17. Lin, F.J., Tsai, M.J., and Tsai, S.Y. Formation of Artery and Vein: A Tug of War between Different Forces. EMBO reports (10):920-4, 2007 (SCI, IF 9.42, 34/297, Biochemistry & Molecular Biology)
18. Tsai, M.J., You, L.R., Lin, F.J., and Tsai, S.Y. Essential role of COUP-TFII in vascular formation. Kidney International 68: 1962–1963, 2005 (SCI, IF 19.00, 3/90, Urology & Nephrology)
19. You, L.R., Lin, F.J., Lee, C.T., DeMayo, F.J., Tsai, M.J., and Tsai, S.Y. Suppression of Notch Signaling by the COUP-TFII transcription factor regulates vein identity. Nature 435(7038): 98-104, 2005 (SCI, IF 69.50, 1/74, Multidisciplinary Sciences)
20. Chao, P.M., Hsu, S.C., Lin, F.J., Li, Y.J., and Huang, C.J. The up-regulation of hepatic acyl-CoA oxidase and cytochrome P450 4A1 mRNA expression by dietary oxidized frying oil is comparable between male and female rats. Lipids. 39(3):233-8, 2004 (SCI, IF 1.65, 76/90, Nutrition & Dietetics)
21. Chao, P.M., Chao, C.Y., Lin, F.J. and Huang, C.J. Oxidized Frying Oil Up-Regulates Hepatic Acyl-CoA Oxidase and Cytochrome P₄₅₀4A1 Genes in Rats and Activates PPARalpha. Journal of Nutrition 131: 3166-3174, 2001 (SCI, IF 4.74, 37/90, Nutrition & Dietetics)