NTUBST2019

• 美國 貝勒醫學院 分子與細胞生物學學系 博士 (2004 ~ 2010) 
• 國立台灣大學  農業化學所 碩士 (2000 ~ 2002)
• 國立台灣大學  農業化學系 學士 (1996  ~ 2000)

表觀遺傳學(Epigenetics)是指在DNA序列不變的情況下，基因受到修飾而改變其表現活性，此種修飾可以藉由遺傳而影響子代的形性。近年來許多研究發現環境會通過表觀遺傳學影響下一代，借此增加生物體及其後代對所處環境的適應力。

我們主要研究興趣為營養素攝入對人體健康和表觀遺傳基礎的影響及其分子機制之探討。由於大部分的表遺傳學改變是可逆的，所以選擇有效的營養素或膳食干預可能可以經由改變表觀遺傳學而進而改善疾病表型。

在我們的實驗室中，我們使用小鼠模型式及細胞培養模式來回答相關生物學問題。其中幾個研究方向:

A. 營養素與表觀基因體調節
B. 脂肪生物學
C. 心血管生物學
D. 癌症生物學

• 國立台灣大學  生化科技學系  副教授 (2020 ~ now)
• 國立台灣大學  生化科技學系  助理教授 (2014 ~ 2020)
• 國立清華大學  分子醫學所  助理教授 (2013 ~ 2014)
• 波士頓兒童醫院/哈佛醫學院  細胞與分子醫學學程  博士後研究員 (2012 ~ 2013)
• 北卡羅萊納大學教堂山分校萊恩伯格綜合癌症中心  博士後研究員 (2011 ~ 2012)
• 貝勒醫學院  分子與細胞生物學  博士後研究員 (2010 ~ 2011)

• 陳尚球教授紀念學術獎, 臺灣營養學會 (May, 2022)
• 2016 Malaspina International Scholar Travel Award(Jan, 2016)
• 國科會補助大專校院延攬特殊優秀人才(2013-2014)
• UNC Lineberger Comprehensive Cancer Center Basic Research Fellowship(2011-2012)
• MCB Outstanding Graduate Award, Baylor College of Medicine March, 2010 Keystone Symposium, National Heart, Lung, and Blood Institute(NHLBI) Scholarship(April, 2010)
• MCB graduate student symposium 3rd place speaker awards, Baylor College of Medicine(April, 2009)
• Alexander Y. Wang Award, Society of Chinese Bioscientists in America(April, 2009)
• Graduate student symposium 2nd place poster award, Baylor College of Medicine(Nov, 2008)
• Keystone Symposium Education Fund Scholarship(Jan, 2008)
• Graduate student symposium 1st place poster award, Baylor College of Medicine(Nov, 2007)
• Pre-doctoral Fellowship, Baylor College of Medicine(2004-2010)
• Professor Jean May Tsiang Foundation Scholarship, Taiwan(April, 2001)

1. Li, C.J., Jiang, C.L., Chao, T.L., Lin, S.Y., Tsai, Y.M., Chao, C.S., Su, Y.T., Chen, C.J., Chang, S.Y.*, Lin, F.J.* and Chang, S.C*. Elicitation of potent neutralizing antibodies in obese mice by ISA 51-adjuvanted SARS-CoV-2 spike RBD-Fc vaccine. Applied Microbiology and Biotechnology, May;107(9):2983-2995, 2023 (SCI, IF 5.56, 31/159, Biotechnology & Applied Microbiology, *corresponding author)
2. Lin, F.J.* Programming of Cardiovascular Disease and Nonalcoholic Fatty Liver Disease: The Role of Maternal Nutrition. Nutritional Sciences Journal, 46 (4): 126-137, 2022 (*first & corresponding author)
3. Wei, Y.S., Lin, W.Z., Wang, T.E., Lee, W.Y., Li, S.H., Lin, F.J., Nixon B., Sipila P., and Tsai P.S. Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1. Journal of Reproduction and Development, Jun 1;68(3):198-208, 2022 (SCI, IF 2.22, 23/62, Agriculture, Dairy & Animal Science)
4. Lin, F.J.* Epigenetics: A New Link Between Nutrition and Health. Nutritional Sciences Journal, 45 (4): 122-140, 2021 (*first & corresponding author)
5. Chen, W.T., Tseng, H.Y., Jiang, C.L., Lee, C.Y., Chi, P., Chen, L.Y., Lo, K.Y., Wang, I.C. and Lin, F.J.* Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation. Journal of Biomedical Science Nov 24;28(1):81, 2021 (SCI, IF 12.77, 11/139, Medicine, Research, Experimental, *corresponding author)
6. Jiang, C.L., Chen, Y.F. and Lin, F.J.* Apolipoprotein E deficiency activates thermogenesis of white adipose tissues in mice through enhancing β-hydroxybutyrate production from precursor cells. FASEB Journal Aug;35(8): e21760, 2021 (SCI, IF 5.83, 16/94, Biology, *corresponding author) Research Highlights in Media: https://medicineinnovates.com/burn-calories-fighting-against-obesity-activating-beige-fat-development/
7. Chen, S.Y., Chen, Y.Z., Lee, Y.J., Jiang, C.L., Lu, S.C. and Lin, F.J.* Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype. Journal of Nutritional Biochemistry Apr; 90:108575, 2021 (SCI, IF 6.12, 18/90, Nutrition & Dietetics, *corresponding author)
8. Chen, H.C., Chen, Y. Z., Wang, C.H. and Lin, F.J.* The nonalcoholic fatty liver disease-like phenotype and lowered serum VLDL are associated with decreased expression and DNA hypermethylation of hepatic ApoB in male offspring of ApoE deficient mothers fed a with Western diet. Journal of Nutritional Biochemistry Mar; 77:108319, 2020 (SCI, IF 6.12, 18/90, Nutrition & Dietetics, *corresponding author)
9. Yang, K.T., Inoue, A., Lee, Y.J., Jiang, C.L. and Lin, F.J.* Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorganization, developmental defects in preimplantation embryos and impaired female fertility. Scientific Reports 9, 18875, 2019 (SCI, IF 5.00, 19/74, Multidisciplinary Sciences, *corresponding author)
10. Wang, Y.J., Lee, S.C., Hsu, C.H., Kuo, Y.H., Yang, C.C., and Lin, F.J.* Antcins, Triterpenoids from Antrodia cinnamomea, as New Agonists for Peroxisome Proliferator-Activated Receptor α. Journal of Food and Drug Analysis Jan; 27(1):295-304, 2019 (SCI, IF 6.16, 27/144, Food Science & Technology, *corresponding author)
11. Lin, F.J., Shen, L., Jang, C.W., Falnes,P.Ø. and Zhang, Y. Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression. PLoS Genetics 9(5): e1003516, 2013 (SCI, IF 6.02, 27/175, Genetics & Heredity)
12. Lin, F. J.^#, You, L. R.^#, Yu, C.T., Hsu, W. H., Tsai, M.J., and Tsai, S.Y. Endocardial Cushion Morphogenesis and Coronary Vessel Development Require COUP-TFII. Arteriosclerosis Thrombosis and Vascular Biology 32(11): e135-46, 2012 (^#equal contribution) (SCI, IF 10.51, 5/67, Peripheral Vascular Disease)
13. Lin, F. J., Qin, J., Tang, K., Tsai, S.Y., and Tsai, M.J. COUP D’ETAT: An Orphan Takes Control. Endocrine Reviews. 32(3):404-21, 2011(SCI, IF 25.26, 4/146, Endocrinology & Metabolism)
14. Lin, F. J., Chen, X., Qin, J., Hong, Y. K., Tsai, M.J., and Tsai, S.Y. Direct transcriptional regulation of Nrp2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. Journal of Clinical Investigation 120(5):1694-707, 2010 (SCI, IF 19.48, 2/139, Medicine, Research, Experimental)
15. Li, Y.J., Luo, S.C., Lee, Y.J., Lin, F.J., Cheng, C.C., Wein, Y.S., Kuo, Y.H., and Huang, C.J. Isolation and identification of alpha-CEHC sulfate in rat urine and an improved method for the determination of conjugated alpha-CEHC. Journal of Agricultural and Food Chemistry 56 (23):11105-13, 2008 (SCI, IF 5.90, 6/59, Agriculture, Multidisciplinary)
16. Srinivasan, R.S., Dillard, M.E., Lagutin, O.V., Lin, F.J., Tsai, S.Y., Tsai, M.J., Samokhvalov I.M., and Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes and Development 21(19):2422-32, 2007 (SCI, IF 12.89, 2/39, Developmental Biology)
17. Lin, F.J., Tsai, M.J., and Tsai, S.Y. Formation of Artery and Vein: A Tug of War between Different Forces. EMBO reports (10):920-4, 2007 (SCI, IF 9.42, 34/297, Biochemistry & Molecular Biology)
18. Tsai, M.J., You, L.R., Lin, F.J., and Tsai, S.Y. Essential role of COUP-TFII in vascular formation. Kidney International 68: 1962–1963, 2005 (SCI, IF 19.00, 3/90, Urology & Nephrology)
19. You, L.R., Lin, F.J., Lee, C.T., DeMayo, F.J., Tsai, M.J., and Tsai, S.Y. Suppression of Notch Signaling by the COUP-TFII transcription factor regulates vein identity. Nature 435(7038): 98-104, 2005 (SCI, IF 69.50, 1/74, Multidisciplinary Sciences)
20. Chao, P.M., Hsu, S.C., Lin, F.J., Li, Y.J., and Huang, C.J. The up-regulation of hepatic acyl-CoA oxidase and cytochrome P450 4A1 mRNA expression by dietary oxidized frying oil is comparable between male and female rats. Lipids. 39(3):233-8, 2004 (SCI, IF 1.65, 76/90, Nutrition & Dietetics)
21. Chao, P.M., Chao, C.Y., Lin, F.J. and Huang, C.J. Oxidized Frying Oil Up-Regulates Hepatic Acyl-CoA Oxidase and Cytochrome P₄₅₀4A1 Genes in Rats and Activates PPARalpha. Journal of Nutrition 131: 3166-3174, 2001 (SCI, IF 4.74, 37/90, Nutrition & Dietetics)