NTUBST2019

• 國立臺灣大學 農業化學所 博士 (1995/09 ~ 1999/10)
• 國立臺灣大學 農業化學系 學士 (1990/09 ~ 1994/06)

• 本研究室致力於人類新興感染症之相關研究工作，尤其著重在新型流感病毒(Influenza virus)、茲卡病毒 (Zika virus)、中東呼吸道症候群冠狀病毒 (MERS-CoV)、新型冠狀病毒 (SARS-CoV-2) 及猴痘病毒 (Monkeypox virus) 之中和性單株抗體與疫苗的研發。針對上述之多種病毒，我們已研發出一系列具有高專一性及病毒中和力的單株抗體，並且成功運用於快篩及分子檢測平台之開發，相關研究成果已發表於國際期刊及進行技轉授權，希望對新興感染症的研究、診斷與治療領域能有所貢獻。

• 本研究室亦投入蝦肝胰腺微孢子蟲病 (Enterocytozoon hepatopennaei; EHP)、急性肝胰腺壞死症 (acute hepatopancreas necrosis disease; AHPND) 及高致死性弧菌病 (highly lethal vibrio disease; HLVD) 等蝦類新興感染症之研究。這些新興蝦類傳染病可造成蝦隻生長遲緩、免疫力下降及肝胰腺上皮細胞死亡，最後造成蝦隻大量死亡，致死率高達100%，因此已經對養蝦產業造成極大的威脅。本研究室已開發出高靈敏度的蝦病快篩試劑，尤其快篩具有簡便、快速且成本低之特色，能夠幫助蝦養殖戶儘早辨識出病蝦，進而進行養殖管控，以阻斷病原的大流行，減低重大的經濟損失。相關計畫的執行，除了可以實際協助養蝦產業提升疾病的檢測與防禦能力，計畫參與人員也能累積跨領域的研究經驗，為生技產業培育優秀的研發人才。

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• 生化科技學系 教授 (2017/08 ~ now)
• 生化科技學系 副教授 (2012/08 ~ 2017/07)
• 生化科技學系 助理教授 (2006/08 ~ 2012/07)
• 美國哈佛大學醫學院細胞生物學系 博士後研究員 (2001/08 ~ 2005/07)

• 臺灣大學教學優良獎 (2024)
• 臺灣大學教學傑出獎 (2019)
• 臺灣大學教學優良獎 (2018)
• 臺灣大學教學優良獎 (2017)
• 臺灣大學教學優良獎 (2011)

1. Liang CY, Chao TL, Chao CS, Liu WD, Cheng YC, Chang SY*, Chang SC* (2024) Monkeypox virus A29L protein as the target for specific diagnosis and serological analysis. Appl Microbiol Biotechnol. 108:522. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/158) *Corresponding author
2. Chang TY, Li CJ, Chao TL, Chang SY*, Chang SC* (2024) Design of the conserved epitope peptide of SARS-CoV-2 spike protein as the broad-spectrum COVID-19 vaccine. Appl Microbiol Biotechnol. 108(1):486. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/158) *Corresponding author
3. Li CJ, Chang SC* (2023) SARS-CoV-2 spike S2-specific neutralizing antibodies. Emerg Microbes Infect. 12(2):2220582 (MICROBIOLOGY ranking: 7/137) *Corresponding author
4. Li CJ, Jiang CL, Chao TL, Lin SY, Tsai YM, Chao CS, Su YT, Chen CJ, Chang SY*, Lin FJ*, and Chang SC* (2023) Elicitation of potent neutralizing antibodies in obese mice by ISA 51-adjuvanted SARS-CoV-2 spike RBD-Fc vaccine. Appl Microbiol Biotechnol. 107(9):2983-2995. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/159) *Corresponding author

5. Hsiao CC, Chiang YW, Chao TL, Tsai ZU, Wang TX, Jiang YW, Hsu HF, Lu DC, Wang JT, Wang JR*, Wang AB*, Chang SY*, and Chang SC* (2022) Simultaneous detection of antibody responses to multiple SARS-CoV-2 antigens by a Western blot serological assay. Appl Microbiol Biotechnol. 106(24):8183-8194. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/159) *Corresponding author

6. Lai GC, Chao TC, Lin SY, Kao HC, Tsai YM, Lu DC, Chiang YW, Chang SY*, Chang SC* (2022) Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain. Antiviral Res. 200:105290 (PHARMACOLOGY & PHARMACY Ranking: 16/279) *Corresponding author
7. Li CJ, Chao TL, Chang TY, Hsiao CC, Lu DC, Chiang YW, Lai GC, Tsai YM, Fang JT, Ieong S, Wang JT, Chang SY*, Chang SC* (2022) Neutralizing monoclonal antibodies inhibit SARS-CoV-2 infection through blocking membrane fusion. Microbiol Spectr. 10(2):e0181421 (MICROBIOLOGY Ranking: 20/137) *Corresponding author
8. Li CJ, Huang PH, Chen HW, Chang SC* (2021) Development and characterization of mouse monoclonal antibodies targeting to distinct epitopes of Zika virus envelope protein for specific detection of Zika virus. Appl Microbiol Biotechnol. 105(11):4663-4673. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/159) *Corresponding author
9. Chiang YW, Li CJ, Su HY, Hsieh KT, Weng CW, Chen HW, Chang SC* (2021) Development of mouse monoclonal antibody for detecting hemagglutinin of avian influenza A(H7N9) virus and preventing virus infection. Appl Microbiol Biotechnol. 105(8):3235-3248. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/159) *Corresponding author
10. Cheng YC, Chang SC* (2021) Development and biochemical characterization of the monoclonal antibodies for specific detection of the emerging H5N8 and H5Nx avian influenza virus hemagglutinins. Appl Microbiol Biotechnol. 105(1):235-245. (BIOTECHNOLOGY & APPLIED MICROBIOLOGY Ranking: 37/159) *Corresponding author
11. Shin YC, Chen JH, Chang SC* (2017) The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2. Sci Rep. 7(1): 2304. (MULTIDISCIPLINARY SCIENCES Ranking: 19/74) *Corresponding author
12. Lin YC, Chang SC*, Juang RH* (2017) Plastidial α-glucan phosphorylase 1 complexes with disproportionating enzyme 1 in Ipomoea batatas storage roots for elevating malto-oligosaccharide metabolism. PLoS ONE 12(5): e0177115. (MULTIDISCIPLINARY SCIENCES Ranking: 29/74) *Corresponding author
13. Hu, CJ, Chien, CY, Liu, MT, Fang, ZS, Chang, SY, Juang, RH, Chang, SC, Chen, HW. Multi-antigen avian influenza a (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. BMC Biotechnol 2017; 17(1): 2.(SCI)
14. Liu CY, Lu DC, Jiang YW, Yen YK, Chang SC*, and Wang AB*. (2016). Easy and fast western blotting by thin-film direct coating with suction. Anal Chem. 88(12):6349-56. (CHEMISTRY, ANALYTICAL Ranking: 7/87) *Corresponding author
15. He JL, Chiu YC, Chang SC, Wang CH, Juang RH. Glycosylation at hemagglutinin Asn-167 protects the H6N1 avian influenza virus from tryptic cleavage at Arg-201 and maintains the viral infectivity. Virus Res 2015; 197: 101-7.(SCI)
16. Young GH, Huang TM, Wu CH, Lai CF, Hou CC, Peng KY, Liang CJ, Lin SL, Chang SC, Tsai PR, Wu KD, Wu VC, Ko WJ. Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor. Antioxid Redox Signal 2014; 20(8): 1181-94.(SCI)
17. Yen YK, Jiang YW, Chang SC*, Wang AB*. (2014) Western blotting by thin-film direct coating. Anal Chem. 86(10):5164-70. (CHEMISTRY, ANALYTICAL Ranking: 7/87) *Corresponding author
18. Huang TF, Cho CY, Cheng YT, Huang JW, Wu YZ, Yeh AY, Nishiwaki K, Chang SC, Wu YC. BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans. PLoS Genet 2014; 10(6): e1004428.(SCI)
19. Sun CY, Chang SC, Wu MS. Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition. PLoS One. 2012; 7(3): e34026. (SCI)
20. Sun CY, Chang SC, Wu MS. Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int.  2012; 81(7): 640-50. (SCI)
21. Lin YC, Chen HM, Chou IM, Chen AN, Chen CP, Young GH, Lin CT, Cheng CH, Chang SC*, Juang RH*. (2012) Plastidial starch phosphorylase in sweet potato roots is proteolytically modified by protein-protein interaction with the 20S proteasome. PLoS ONE 7(4): e35336. (MULTIDISCIPLINARY SCIENCES Ranking: 29/74) *Corresponding author
22. Shin YC, Tang SJ, Chen JH, Liao PH and Chang SC*. (2011) The molecular determinants of NEDD8 specific recognition by human SENP8. PLoS ONE 6(11): e27742. (MULTIDISCIPLINARY SCIENCES Ranking: 29/74) *Corresponding author
23. Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, Goldberg AL, Stratikos E, Stern LJ. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol. 2011; 18(5): 604-13. (SCI)
24. Liu LR, Lin SP, Chen CC, Chen YJ, Tai CC, Chang SC, Juang RH, Tseng YW, Liu BH, Mersmann HJ, Shen TL, Ding ST. Serum Amyloid A Induces Lipolysis by Downregulating Perilipin Through ERK1/2 and PKA Signaling Pathways. Obesity (Silver Spring). 2011. (SCI)
25. Shin YC, Liu BY, Tsai JY, Wu JT, Chang LK and Chang SC*. (2010) Biochemical characterization of the small ubiquitin-like modifiers of Chlamydomonas reinhardtii. Planta 232(3):649-62. (PLANT SCIENCES Ranking: 44/239) *Corresponding author
26. Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell. 2008; 30(3): 360-8. (SCI)
27. Evnouchidou I, Momburg F, Papakyriakou A, Chroni A, Leondiadis L, Chang SC, Goldberg AL, Stratikos E. The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS One. 2008; 3(11): e3658. (SCI)
28. Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell. 2007; 27(5): 731-44. (SCI)
29. Chang SC, Momburg F, Bhutani N, Goldberg AL. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci U S A. 2005; 102(47): 17107-12. (SCI)
30. Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med. 2004; 199(7): 905-15. (SCI)
31. York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol. 2002; 3(12): 1177-84. (SCI)
32. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol. 2002; 3(12): 1169-76. (SCI)
33. Chen HM, Chang SC, Wu CC, Cuo TS, Wu JS, Juang RH. Regulation of the catalytic behaviour of L-form starch phosphorylase from sweet potato roots by proteolysis.Physiol Plant. 2002; 114(4): 506-15. (SCI)
34. Chang SC, Lin PC, Chen HM, Wu JS, Juang RH. The isolation and characterization of Chaperonin 60 from sweet potato roots - Involvement of the chaperonins in starch biosynthesis. Bot Bul Acad Sin. 2000; 41(2): 105-11. (SCI)