NTUBST2019

• 佛羅里達大學 植病系 博士 (2006/09-2010/05)
• 國立中興大學 分生所 碩士 (2002/09-2004/06)
• 中山醫學大學 醫技系 學士 (1993/09-1997/06)

白色念株球菌(Candida albicans) 是人體皮膚和腸道內常見的真菌之一。一般情況下，此真菌不會對健康的人造成任何威脅。然而，對於免疫力不足的病人 (經化療或後天免疫不全的患者)，則易造成系統性的嚴重感染。實驗室目前主要從事下列研究方向，包括生物膜 (biofilm) 形成的機制、致病機轉、white-opaque 形態轉換、sexual cycle 與其相關的訊息傳導。

• 國立台灣大學 生化科技學系  教授 (2022/08 ~ now)
• 國立台灣大學 生化科技學系  副教授 (2017/08 ~ 2022/07)
• 國立台灣大學 生化科技學系  助理教授 (2012/08 ~ 2017/07)
• 布朗大學分子微免所  博士後研究員 (2010/07 ~ 2012/06)
• 佛羅里達大學植病系  博士後研究員 (2010/05 ~ 2010/06)
• 中興大學分生所  研究助理 (2004/08 ~ 2006/08)
• 健仁醫院臨床生化與血清免疫  醫檢師 (1999/09 ~ 2002/04)

服務

• 國立台灣大學 環安衛中心 主任 (2023/01 ~ now)
• 國立台灣大學 創意創業學程  主任 (2022/04 ~ now)
• 國立台灣大學 環安衛中心 副主任 (2019/08 ~ 2023/01)
• 國立台灣大學 創意創業學程  副主任 (2016/10 ~ 2022/03)
• 國立台灣大學 環安衛中心 生污組組長 (2017/08 ~ 2021/12)
• 國立台灣大學 創新設計學院 創業教育組組長 (2019/03 ~ 2021/05)
• 國立台灣大學 創意創業學程  代理主任 (2016/08 ~ 2016/10)
• 中央研究院  高中生命科學研究人才培育計畫 (2013/05 ~ 2013/12)
• 國立台灣大學 教務處 科技創新與教學成長社群召集人 (2012/11 ~ 2013/12)

• Antimicrobial actions and applications of chitosan. Polymers. 2021; 13:904為Web of Science 2021年與2022年高引用論文
• 國立台灣大學 教學優良 (2022)
• 國立台灣大學 教學優良 (2021)
• 國立台灣大學 教學優良 (2020)
• 國立台灣大學 教學優良 (2018)
• 石佩玉與簡孜同學分別榮獲美國微生物學會 (ASM) 與歐洲 The International Society  for Human & Animal Mycology (ISHAM) Travel Support (2018).
• 石佩玉、簡孜庭同學遴選為美國 2018 14th ASM Conference of Candida and Candidiasis 論文口頭報告。Providence, RI, U.S.A. (2018)
• 科技部 傑出學者養成計畫 (2016-2019)
• 國立台灣大學 教學優良 (2016)
• 國立台灣大學 教學優良 (2015)
• 科技部 優秀年輕學者計畫 (2014-2017)
• 梁慎桓同學獲美國微生物學會Young Investigator Award at the 12th ASM Conference of Candida and Candidiasis (2014/03)
• 梁慎桓同學獲美國微生物學會 Travel Award (2014/01)
• 美國微生物學會 (ASM) Eukaryotic Cell Outstanding Young Investigator (2013)
• 美國 F. A. Travel Award (2010)
• 美國 Francis Aloysius Wood Award (2010)
• Outstanding Academic Achievement, University of Florida International Student Center (2007)
• Hunt Brothers Research Fellowhip (2006-2010)
• Grinter Fellowship, University of Florida (2006)

1. Ke CL, Lew SQ, Hsieh Y, Chang SC, Lin CH. Convergent and divergent roles of the glucose-responsive kinase Snf4 in Candida tropicalis. Virulence. 2023 (Accepted). (SCI)
2. Ke CL, Deng FS, Chuang CY, Lin CH. Antimicrobial actions and applications of chitosan. Polymers. 2021; 13:904. (SCI)
3. Ke CL, Liao YT, Lin CH. MSS2 maintains mitochondrial function and is required for chitosan resistance, invasive growth, biofilm formation and virulence in Candida albicans. Virulence. 2021. 12:281-297. (SCI)
4. Lew SQ, Lin CH. N-acetylglucosamine-mediated morphological transition in Candida albicans and Candida tropicalis. Curr Genet. 2021; 67:249-254. (SCI)
5. Lin CH. mSphere of Influence: Turning to soil for medicines. mSphere. 2021. 6:01258. (SCI)
6. Lo WH, Deng FS, Chang CJ, Lin CH. Synergistic antifungal activity of chitosan with fluconazole against Candida albicans, Candida tropicalis, and fluconazole-resistant strains. Molecules. 2020; 25:5114. doi: 10.3390/molecules25215114. (SCI)
7. Song YD, Hsu CC, Lew SQ, Lin CH. Candida tropicalis RON1 is required for hyphal formation, biofilm development and virulence but is dispensable for N-acetylglucosamine catabolism. Med Mycol. 2021. 59:379-391.. (SCI)
8. Tseng YK, Chen, YC, Hou CJ, Deng, FS, Liang SH, Hoo SY, Hsu CC, Ke CL, Lin CH. Evaluation of biofilm formation in Candida tropicalis using a silicone-based platform with synthetic urine medium. Microorganisms. 2020 8:660. doi: 10.3390/microorganisms8050660. (SCI)
9. Shen M, Li PT, Wu YJ, Lin CH, Chai E, Chang TC, Chen CT. The antifungal activities and biological consequences of BMVC-12C-P, a carbazole derivative against Candida species. Med Mycol. 2020; 58: 521-529. (SCI)
10. Shih PY, Liao YT, Tseng YK, Deng FS, Lin CH. A potential antifungal effect of chitosan against Candida albicans is mediated via the inhibition of SAGA complex component expression and the subsequent alteration of cell surface integrity. Front Microbiol. 2019; 10: 602. doi: 10.3389/fmicb.2019.00602. (SCI)
11. Chien CT, Chen YC, Liu YC, Liang SH, Lin HH, Lin CH. The antimicrobial photodynamic inactivation resistance of Candida albicans is modulated by the Hog1 pathway and the Cap1 transcription factor. Med Mycol.  2019; 57: 618-627. (SCI)
12. ​Lin CH, Chien HF, Lin MH, Chen CP, Shen M, Chen CT. Chitosan inhibits the rehabilitation of damaged microbes induced by photodynamic inactivation. Int J Mol Sci. 2018; 19:2598;doi: 10.3390/ijms19092598. (SCI)
13. Deng FS, Lin CH. Identification and characterization of ORF19.1725, a novel gene contributing to the white cell pheromone response and virulence-associated functions in Candida albicans. Virulence. 2018; 31: 866-878. (SCI)
14. Deng FS, Lin CH. Cpp1 phosphatase mediated signaling crosstalk between Hog1 and Cek1 mitogen-activated protein kinases is involved in the phenotypic transition in Candida albicans. Med Mycol. 2018; 56:242-252.(SCI)
15. Chang WH, Liang SH, Deng FS, Lin CH. The conserved dual phosphorylation sites of the Candida albicans Hog1 protein are crucial for white-opaque switching, mating, and pheromone-stimulated cell adhesion. Med Mycol. 2016; 54(6): 682-640 (MOST103-2628-B-002-003-MY3) (SCI)
16. Lin CH, Chung KR. Interactions of MAP kinases, histidine kinase and YAP1 in the citrus fungal pathogen Alternaria alternata. Plant Pathology bulletin. 2014; 23: 307-315.
17. Liang SH, Cheng JH, Deng FS, Tsai PA, Lin CH. A novel function for Hog1 SAPK in controlling white-opaque switching and mating in Candida albicans.  Eukaryot Cell. 2014; 13(12): 1557-1566. (SCI) (NSC102-2320-B002-027-MY3, MOST103-2628-B-002-003-MY3 and NTU103R7787)
18. Chen LH, Lin CH, Chung KR. A nonribosomal peptide synthetase mediates siderophore production and virulence in the citrus fungal pathogen Alternaria alternata.Mol Plant Pathol 2013; 14(5): 497-505.(SCI)
19. Lin CH, Kabrawala S, Fox EP, Nobile CJ, Johnson AD, Bennett RJ. Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans. 2013; PLoS Pathog. 9(4): e1003305. (SCI) (NSC-101-2320-B-002-050) (Recommend article by Faculty of 1000)
20. Chen LH, Lin CH, Chung KR. Roles for SKN7 response regulator in stress resistance, conidiation and virulence in the citrus pathogen Alternaria alternata. Fungal Genet Biol. 2012; 49(10): 802-13. (SCI)
21. Lin CH, Choi A, Bennett RJ. Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species. Mol Biol Cell. 2011; 22(24): 4918-30. (SCI)
22. Yago JI, Lin CH, Chung KR. The SLT2 mitogen-activated protein kinase-mediated signalling pathway governs conidiation, morphogenesis, fungal virulence and production of toxin and melanin in the tangerine pathotype of Alternaria alternata. Mol Plant Pathol. 2011; 12(7): 653-65. (SCI)
23. Wang NY, Yang SL, Lin CH, Chung KR. Gene inactivation in the citrus pathogenic fungus Alternaria alternata defect at the Ku70 locus associated with non-homologous end joining. World J Microbiol Biotechnol. 2011; 27(8): 1817-26. (SCI)
24. Lin CH, Yang SL, Chung KR. Cellular responses required for oxidative stress tolerance, colonization, and lesion formation by the necrotrophic fungus Alternaria alternata in citrus. Curr Microbiol. 2011; 62(3): 807-15. (SCI)
25. Lin CH, Lee CN, Lin JW, Tsai WJ, Wang SW, Weng SF, Tseng YH. Characterization of Xanthomonas campestris pv. campestris heat shock protein A (HspA), which possesses an intrinsic ability to reactivate inactivated proteins. Appl Microbiol Biotechnol. 2010; 88(3): 699-709. (SCI)
26. Lin CH, Chung KR. Specialized and shared functions of the histidine kinase- and HOG1 MAP kinase-mediated signaling pathways in Alternaria alternata, a filamentous fungal pathogen of citrus. Fungal Genet Biol. 2010; 47(10): 818-27. (SCI)
27. Lin CH, Yang SL, Wang NY, Chung KR. The FUS3 MAPK signaling pathway of the citrus pathogen Alternaria alternata functions independently or cooperatively with the fungal redox-responsive AP1 regulator for diverse developmental, physiological and pathogenic processes. Fungal Genet Biol. 2010; 47(4): 381-91. (SCI)
28. Wang NY, Lin CH, Chung KR. A Gα subunit gene is essential for conidiation and potassium efflux but dispensable for pathogenicity of Alternaria alternata on citrus.Curr Genet. 2010; 56(1): 43-51. (SCI)
29. Yang SL, Lin CH, Chung KR. Coordinate control of oxidative stress tolerance, vegetative growth, and fungal pathogenicity via the AP1 pathway in the rough lemon pathotype of Alternaria alternata. Physiol Mol Plant Pathol. 2009; 74(2): 100-10. (The first two authors contributed equally) (SCI)
30. Lin CH, Yang SL, Chung KR. The YAP1 homolog-mediated oxidative stress tolerance is crucial for pathogenicity of the necrotrophic fungus Alternaria alternata in citrus. Mol Plant Microbe Interact. 2009; 22(8): 942-52. (SCI)
31. Chen CR, Lin CH, Lin JW, Chang CI, Tseng YH, Weng SF. Characterization of a novel T4-type Stenotrophomonas maltophilia virulent phage Smp14. Arch Microbiol. 2007; 188(2): 191-7. (The first two authors contributed equally) (SCI)